MovDisordV3, Main, Exploration, bibRecord, 000A02

Emerging therapies for gait disability and balance impairment: promises and pitfalls.

Identifieur interne : 000A02 ( Main/Exploration ); précédent : 000A01; suivant : 000A03

Emerging therapies for gait disability and balance impairment: promises and pitfalls.

Auteurs : Walter Maetzler [Allemagne] ; Freek Nieuwhof ; Sandra E. Hasmann ; Bastiaan R. Bloem

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.

RBID : pubmed:24132846

English descriptors

KwdEn :
- Emergency Medical Services (methods), Gait Disorders, Neurologic (psychology), Gait Disorders, Neurologic (therapy), Humans, Postural Balance (physiology), Quality of Life, Sensation Disorders (psychology), Sensation Disorders (therapy).
MESH :
- methods : Emergency Medical Services.
- physiology : Postural Balance.
- psychology : Gait Disorders, Neurologic, Sensation Disorders.
- therapy : Gait Disorders, Neurologic, Sensation Disorders.
- Humans, Quality of Life.

Abstract

Therapeutic management of gait and balance impairment during aging and neurodegeneration has long been a neglected topic. This has changed considerably during recent years, for several reasons: (1) an increasing recognition that gait and balance deficits are among the most relevant determinants of an impaired quality of life and increased mortality for affected individuals; (2) the arrival of new technology, which has allowed for new insights into the anatomy and functional (dis)integrity of gait and balance circuits; and (3) based in part on these improved insights, the development of new, more specific treatment strategies in the field of pharmacotherapy, deep brain surgery, and physiotherapy. The initial experience with these emerging treatments is encouraging, although much work remains to be done. The objective of this narrative review is to discuss several promising developments in the field of gait and balance treatment. We also address several pitfalls that can potentially hinder a fast and efficient continuation of this vital progress. Important issues that should be considered in future research include a clear differentiation between gait and balance as two distinctive targets for treatment and recognition of compensatory mechanisms as a separate target for therapeutic intervention.

DOI: 10.1002/mds.25682
PubMed: 24132846

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emerging therapies for gait disability and balance impairment: promises and pitfalls.</title>
<author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name>
<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DNZE), Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DNZE), Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nieuwhof, Freek" sort="Nieuwhof, Freek" uniqKey="Nieuwhof F" first="Freek" last="Nieuwhof">Freek Nieuwhof</name>
</author>
<author><name sortKey="Hasmann, Sandra E" sort="Hasmann, Sandra E" uniqKey="Hasmann S" first="Sandra E" last="Hasmann">Sandra E. Hasmann</name>
</author>
<author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. Bloem</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="doi">10.1002/mds.25682</idno>
<idno type="RBID">pubmed:24132846</idno>
<idno type="pmid">24132846</idno>
<idno type="wicri:Area/PubMed/Corpus">000717</idno>
<idno type="wicri:Area/PubMed/Curation">000717</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000A11</idno>
<idno type="wicri:Area/Ncbi/Merge">003D80</idno>
<idno type="wicri:Area/Ncbi/Curation">003D80</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003D80</idno>
<idno type="wicri:Area/Main/Merge">000A02</idno>
<idno type="wicri:Area/Main/Curation">000A02</idno>
<idno type="wicri:Area/Main/Exploration">000A02</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Emerging therapies for gait disability and balance impairment: promises and pitfalls.</title>
<author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name>
<affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DNZE), Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DNZE), Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nieuwhof, Freek" sort="Nieuwhof, Freek" uniqKey="Nieuwhof F" first="Freek" last="Nieuwhof">Freek Nieuwhof</name>
</author>
<author><name sortKey="Hasmann, Sandra E" sort="Hasmann, Sandra E" uniqKey="Hasmann S" first="Sandra E" last="Hasmann">Sandra E. Hasmann</name>
</author>
<author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. Bloem</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emergency Medical Services (methods)</term>
<term>Gait Disorders, Neurologic (psychology)</term>
<term>Gait Disorders, Neurologic (therapy)</term>
<term>Humans</term>
<term>Postural Balance (physiology)</term>
<term>Quality of Life</term>
<term>Sensation Disorders (psychology)</term>
<term>Sensation Disorders (therapy)</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Emergency Medical Services</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Gait Disorders, Neurologic</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Quality of Life</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Therapeutic management of gait and balance impairment during aging and neurodegeneration has long been a neglected topic. This has changed considerably during recent years, for several reasons: (1) an increasing recognition that gait and balance deficits are among the most relevant determinants of an impaired quality of life and increased mortality for affected individuals; (2) the arrival of new technology, which has allowed for new insights into the anatomy and functional (dis)integrity of gait and balance circuits; and (3) based in part on these improved insights, the development of new, more specific treatment strategies in the field of pharmacotherapy, deep brain surgery, and physiotherapy. The initial experience with these emerging treatments is encouraging, although much work remains to be done. The objective of this narrative review is to discuss several promising developments in the field of gait and balance treatment. We also address several pitfalls that can potentially hinder a fast and efficient continuation of this vital progress. Important issues that should be considered in future research include a clear differentiation between gait and balance as two distinctive targets for treatment and recognition of compensatory mechanisms as a separate target for therapeutic intervention.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
</region>
<settlement><li>Tübingen</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. Bloem</name>
<name sortKey="Hasmann, Sandra E" sort="Hasmann, Sandra E" uniqKey="Hasmann S" first="Sandra E" last="Hasmann">Sandra E. Hasmann</name>
<name sortKey="Nieuwhof, Freek" sort="Nieuwhof, Freek" uniqKey="Nieuwhof F" first="Freek" last="Nieuwhof">Freek Nieuwhof</name>
</noCountry>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A02 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A02 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:24132846
   |texte=   Emerging therapies for gait disability and balance impairment: promises and pitfalls.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24132846" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Emerging therapies for gait disability and balance impairment: promises and pitfalls.

Emerging therapies for gait disability and balance impairment: promises and pitfalls.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.